| http://purl.uniprot.org/citations/10207147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10207147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10207147 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified six protein kinases that belong to the family of cdc2-related kinases in Caenorhabditis elegans. Results from RNA interference experiments indicate that at least one of these kinases is required for cell-cycle progression during meiosis and mitosis. This kinase, encoded by the ncc-1 gene, is closely related to human Cdk1/Cdc2, Cdk2 and Cdk3 and yeast CDC28/cdc2(+). We addressed whether ncc-1 acts to promote passage through a single transition or multiple transitions in the cell cycle, analogous to Cdks in vertebrates or yeasts, respectively. We isolated five recessive ncc-1 mutations in a genetic screen for mutants that resemble larval arrested ncc-1(RNAi) animals. Our results indicate that maternal ncc-1 product is sufficient for embryogenesis, and that zygotic expression is required for cell divisions during larval development. Cells that form the postembryonic lineages in wild-type animals do not enter mitosis in ncc-1 mutants, as indicated by lack of chromosome condensation and nuclear envelope breakdown. However, progression through G1 and S phase appears unaffected, as revealed by expression of ribonucleotide reductase, incorporation of BrdU and DNA quantitation. Our results indicate that C. elegans uses multiple Cdks to regulate cell-cycle transitions and that ncc-1 is the C. elegans ortholog of Cdk1/Cdc2 in other metazoans, required for M phase in meiotic as well as mitotic cell cycles."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.10.2227"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.10.2227"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/author | "Srinivasan D.G."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/author | "Srinivasan D.G."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/pages | "2227-2239"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/pages | "2227-2239"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase."xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/10207147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10207147 |
| http://purl.uniprot.org/citations/10207147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10207147 |
| http://purl.uniprot.org/citations/10207147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10207147 |
| http://purl.uniprot.org/citations/10207147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10207147 |