| http://purl.uniprot.org/citations/10209036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10209036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10209036 | http://www.w3.org/2000/01/rdf-schema#comment | "T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs. We describe here a novel molecule of this group termed SIT (SHP2 interacting transmembrane adaptor protein). SIT is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes. After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif. Overexpression of SIT in Jurkat cells downmodulates T cell receptor- and phytohemagglutinin-mediated activation of the nuclear factor of activated T cells (NF-AT) by interfering with signaling processes that are probably located upstream of activation of phospholipase C. However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.189.8.1181"xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.189.8.1181"xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Shevchenko A."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Shevchenko A."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Autschbach F."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Autschbach F."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Bruyns E."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Bruyns E."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Kirchgessner H."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Kirchgessner H."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Meuer S."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Meuer S."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Ratnofsky S."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/author | "Ratnofsky S."xsd:string |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10209036 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |