| http://purl.uniprot.org/citations/10210776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10210776 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines and growth factors regulate expression of their target genes via the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) signaling pathway. One of the best characterized targets of STAT is the interleukin-2 receptor-alpha (IL-2Ralpha) gene. Its transcription is controlled by interleukin 2 (IL-2) through STAT5 activation. Using the PC60 cell line, in which the role of STAT5 in the regulation of the murine IL-2Ralpha gene by IL-2 has been elucidated, we have compared the response of this gene to IL-2, interleukin-9 (IL-9) and erythropoietin (Epo). IL-2 and IL-9, but not Epo, stimulate cell surface expression of IL-2Ralpha. This correlates with the fact that IL-2 and IL-9 support long-term STAT5 activation whereas Epo only induces transient activation. In cells treated with vanadate, a protein tyrosine phosphatase (PTP) inhibitor, Epo induces prolonged STAT5 activation and strongly stimulates IL-2Ralpha expression. Our study suggests that by controlling the duration of the STAT activation signal, PTP influences the specificity of cytokine signaling."xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/author | "Imbert V."xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/author | "Renauld P.R."xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/name | "Eur Cytokine Netw"xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/pages | "71-78"xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/title | "Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines."xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/10210776 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10210776 |
| http://purl.uniprot.org/citations/10210776 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10210776 |
| http://purl.uniprot.org/uniprot/P26897#attribution-78A4B45E899E939FBC9C5028EFA685A2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10210776 |
| http://purl.uniprot.org/uniprot/#_P26897-mappedCitation-10210776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10210776 |
| http://purl.uniprot.org/uniprot/P26897 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10210776 |