| http://purl.uniprot.org/citations/10212258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10212258 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells from individuals with the recessive cancer-prone disorder ataxia telangiectasia (A-T) are hypersensitive to ionizing radiation (I-R). ATM (mutated in A-T) is a protein kinase whose activity is stimulated by I-R. c-Abl, a nonreceptor tyrosine kinase, interacts with ATM and is activated by ATM following I-R. Rad51 is a homologue of bacterial RecA protein required for DNA recombination and repair. Here we demonstrate that there is an I-R-induced Rad51 tyrosine phosphorylation, and this induction is dependent on both ATM and c-Abl. ATM, c-Abl, and Rad51 can be co-immunoprecipitated from cell extracts. Consistent with the physical interaction, c-Abl phosphorylates Rad51 in vitro and in vivo. In assays using purified components, phosphorylation of Rad51 by c-Abl enhances complex formation between Rad51 and Rad52, which cooperates with Rad51 in recombination and repair. After I-R, an increase in association between Rad51 and Rad52 occurs in wild-type cells but not in cells with mutations that compromise ATM or c-Abl. Our data suggest signaling mediated through ATM, and c-Abl is required for the correct post-translational modification of Rad51, which is critical for the assembly of Rad51 repair protein complex following I-R."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.18.12748"xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Song B."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Goff S.P."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Cong F."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Park M.S."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Lee E.Y."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Trujillo K."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Yuan S.S."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Gasser P.J."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/author | "Arlinghaus R."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/pages | "12748-12752"xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/title | "Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl."xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10212258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10212258 |
| http://purl.uniprot.org/citations/10212258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10212258 |