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http://purl.uniprot.org/citations/10213691http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10213691http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10213691http://www.w3.org/2000/01/rdf-schema#comment"The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex in rat liver also includes Rbx1, an evolutionarily conserved protein that contains a RING-H2 fingerlike motif and that interacts with Cullins. The yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCFCdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 and for the G1 to S cell cycle transition. These findings provide a further link between VHL and the cellular ubiquitination machinery."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.org/dc/terms/identifier"doi:10.1126/science.284.5414.657"xsd:string
http://purl.uniprot.org/citations/10213691http://purl.org/dc/terms/identifier"doi:10.1126/science.284.5414.657"xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Elledge S.J."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Elledge S.J."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Lane W.S."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Lane W.S."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Conaway J.W."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Conaway J.W."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Conaway R.C."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Conaway R.C."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Harper J.W."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Harper J.W."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Koepp D.M."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Koepp D.M."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Conrad M.N."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Conrad M.N."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Kamura T."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Kamura T."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Skowyra D."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Skowyra D."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Moreland R.J."xsd:string
http://purl.uniprot.org/citations/10213691http://purl.uniprot.org/core/author"Moreland R.J."xsd:string