| http://purl.uniprot.org/citations/10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10215625 | http://www.w3.org/2000/01/rdf-schema#comment | "Specific mutations in some tumor suppressor genes such as p53 can act in a dominant fashion. We tested whether this mechanism may also apply for the neurofibromatosis type-2 gene (NF2) which, when mutated, leads to schwannoma development. Transgenic mice were generated that express, in Schwann cells, mutant NF2 proteins prototypic of natural mutants observed in humans. Mice expressing a NF2 protein with an interstitial deletion in the amino-terminal domain showed high prevalence of Schwann cell-derived tumors and Schwann cell hyperplasia, whereas those expressing a carboxy-terminally truncated protein were normal. Our results indicate that a subset of mutant NF2 alleles observed in patients may encode products with dominant properties when overexpressed in specific cell lineages."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.13.8.978"xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "van der Valk M."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Goutebroze L."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Giovannini M."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Merel P."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Niwa-Kawakita M."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Robanus-Maandag E."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/author | "Woodruff J.M."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/pages | "978-986"xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/title | "Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein."xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/10215625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10215625 |
| http://purl.uniprot.org/citations/10215625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10215625 |
| http://purl.uniprot.org/uniprot/#_E9Q7I0-mappedCitation-10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10215625 |
| http://purl.uniprot.org/uniprot/#_F8WJ43-mappedCitation-10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10215625 |
| http://purl.uniprot.org/uniprot/#_F7D6P2-mappedCitation-10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10215625 |
| http://purl.uniprot.org/uniprot/#_F7DBY2-mappedCitation-10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10215625 |
| http://purl.uniprot.org/uniprot/#_E9PW99-mappedCitation-10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10215625 |
| http://purl.uniprot.org/uniprot/#_F6X089-mappedCitation-10215625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10215625 |