| http://purl.uniprot.org/citations/10220507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10220507 | http://www.w3.org/2000/01/rdf-schema#comment | "Background & aimsTransporter associated with antigen processing (TAP) has essential roles in the antigen-presenting systems, translocating antigenic peptides from the cytosol into the endoplasmic reticulum. The aim of this study was to clarify whether TAP polymorphisms are involved in hepatitis C virus (HCV) infection.MethodsThe 145 HCV-infected Japanese patients examined in this study were categorized into two groups: 36 carriers with persistently normal alanine transaminase (ALT) values and 109 patients with chronic liver disease (CLD). TAP2 gene phenotypes were determined by means of polymerase chain reaction-restriction fragment length polymorphism, and their frequencies were compared between the two groups.ResultsFrequencies of TAP2*0101, *0102, and *0201 were not different between the two groups. However, TAP2*0103 frequency in carriers with normal ALT levels was significantly higher than that in patients with CLD (44% vs. 16%; P = 0.00064, Pc < 0.005). Although the TAP2*0103 allele was tightly linked with class II DRB1*1302-DQB1*0604 haplotype in this study, the TAP2*0103 frequency in the normal ALT group was also significantly higher than that in the CLD group even in DRB1*1302-DQB1*0604-negative patients (31% vs. 10%; P = 0.0076, Pc < 0.05).ConclusionsThese findings suggest that TAP2*0103 may be closely associated with low serum ALT activity in HCV-infected Japanese patients."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0016-5085(99)70018-1"xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Hayashi N."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Ito A."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Katayama K."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Hori M."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Takehara T."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Tatsumi T."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Moribe T."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Ohkawa K."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Kanto T."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Kasahara A."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/author | "Kuzushita N."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/name | "Gastroenterology"xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/pages | "1149-1154"xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/title | "Involvement of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in hepatitis C virus infection."xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/10220507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10220507 |
| http://purl.uniprot.org/citations/10220507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10220507 |
| http://purl.uniprot.org/uniprot/#_Q15547-mappedCitation-10220507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10220507 |
| http://purl.uniprot.org/uniprot/#_A0A1V0E419-mappedCitation-10220507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10220507 |
| http://purl.uniprot.org/uniprot/#_A0A1V0E3X6-mappedCitation-10220507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10220507 |