| http://purl.uniprot.org/citations/10221647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10221647 | http://www.w3.org/2000/01/rdf-schema#comment | "Alloreactivity, the capacity of a large number of T lymphocytes to react with foreign MHC molecules, represents the cellular basis for the rejection of tissue grafts. Although it was originally assumed that the TCR of alloreactive T cells focus their recognition on the polymorphic residues that differ between the MHC molecules of responder and stimulator cells, studies in the MHC class I system have clearly demonstrated that MHC-bound peptides can influence this interaction. It remains unclear, however, whether peptides play an equally important role for the recognition of MHC class II molecules by alloreactive CD4+ T cells. Another issue that remains unresolved is the overall frequency of peptide-dependent versus peptide-independent alloreactive T cells. We have addressed these questions with antigen-presenting cells (APC) from H2-M mutant mice that predominantly express a single MHC class II-peptide complex, H2-Ab bound by a peptide (CLIP) derived from the class II-associated invariant chain. APC from these mice were used as targets and stimulators for alloreactive CD4+ T cells. Results demonstrated that the vast majority of CD4+ alloreactive T cells recognize MHC class II molecules in a peptide-dependent fashion."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/11.3.351"xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/author | "Hong S."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/author | "Singh N."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/author | "Martin W.D."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/author | "Mendiratta S.K."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/author | "Kovalik J.P."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/pages | "351-360"xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/title | "Peptide dependency of alloreactive CD4+ T cell responses."xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10221647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10221647 |
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