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http://purl.uniprot.org/citations/10226549http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10226549http://www.w3.org/2000/01/rdf-schema#comment"

Background

Thymidylate synthetase and thymidine kinase are key enzymes involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively.

Materials and methods

Weekly injections of 1,2-dimethyl-hydrazine induced high incidence of colorectal adenocarcinomas in rats.

Results

An increased activity of thymidylate synthetase was found in the poorly differentiated adenocarcinomas of the chemically induced rat colorectal tumors. Six-week oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil (UFT) reduced the total number of colorectal tumors, with the reduction of thymidylate synthetase activity in the poorly-differentiated type, though the mRNA expression of thymidylate synthetase and thymidine kinase differed little between the groups with or without UFT treatment.

Conclusions

These results indicate that the long-term oral administration using UFT suppresses colorectal carcinogenesis and the growth of the poorly-differentiated type tumors."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Hara Y."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Nakayama T."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Suzuki T."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Sassa S."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Mitamura T."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Sakamoto S."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Kudo H."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Yoshimura S."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Iwama T."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Kawachi Y."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Ohsawa M."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Kuwa K."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/author"Maemura T."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/pages"245-250"xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/title"Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors."xsd:string
http://purl.uniprot.org/citations/10226549http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/10226549http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10226549
http://purl.uniprot.org/citations/10226549http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10226549
http://purl.uniprot.org/uniprot/#_A0A8I6G9V7-mappedCitation-10226549http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10226549
http://purl.uniprot.org/uniprot/#_P45352-mappedCitation-10226549http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10226549
http://purl.uniprot.org/uniprot/A0A8I6G9V7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/10226549
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