| http://purl.uniprot.org/citations/10227971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10227971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10227971 | http://www.w3.org/2000/01/rdf-schema#comment | "Viral strategies for immune evasion include inhibition of various steps in the class I MHC assembly pathway. Here, we demonstrate that adenovirus produces one gene product with a dual function in this regard. It is well established that adenovirus E19 binds class I molecules and retains them in the endoplasmic reticulum (ER). However, E19 also delays the expression of class I alleles to which it cannot tightly bind. Here, we show that E19 binds TAP and acts as a tapasin inhibitor, preventing class I/TAP association. DeltaE19, an E19 mutant lacking the ER-retention signal, delays maturation of class I molecules, indicating that E19's inhibition of class I/TAP interaction is sufficient to delay class I expression. These data identify tapasin inhibition as a novel mechanism of viral immune evasion and suggest that, through this secondary mechanism, adenovirus can affect Ag presentation by MHC alleles that it can only weakly affect by direct retention."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Bennett E.M."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Bennett E.M."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Bennink J.R."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Bennink J.R."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Brodsky F.M."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Brodsky F.M."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Yewdell J.W."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/author | "Yewdell J.W."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/pages | "5049-5052"xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/pages | "5049-5052"xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/title | "Adenovirus E19 has two mechanisms for affecting class I MHC expression."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/title | "Adenovirus E19 has two mechanisms for affecting class I MHC expression."xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/10227971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10227971 |
| http://purl.uniprot.org/citations/10227971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10227971 |
| http://purl.uniprot.org/citations/10227971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10227971 |
| http://purl.uniprot.org/citations/10227971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10227971 |