| http://purl.uniprot.org/citations/10228021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10228021 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class Ia-deficient mice (H2 Kb-/-Db-/-) inoculated with the intracellular pathogen Listeria monocytogenes (LM) displayed a three-to fourfold expansion of splenic CD8+ T cells 6 days following infection. Culture of these spleen cells in vitro gave rise to CTL that recognized LM-infected target cells and were restricted by the class Ib molecules, Qa1b and M3. Exposure of target cells to heat-killed LM (HKLM) rather than live bacteria did not result in CTL-mediated lysis. Target cells pulsed with three LM peptides known to bind M3, f-MIGWII, f-MIVTLF, and f-MIVIL, were recognized by effector cells from both B6 and Kb-/- Db-/-animals. In vivo analysis showed that B6 and Kb-/- Db-/-mice clear LM from the spleen and liver rapidly with similar kinetics, whereas TAP.1-/-mice, which are deficient in class Ia and Ib molecules, clear LM slowly upon infection. To establish the in vivo role of CD8+ T cells in Kb-/- Db-/-animals, we showed that depletion of such cells from the spleens of immune mice prevented the adoptive transfer of protective immunity to syngeneic recipients. Spleen cells from Kb-/- Db-/-mice were also capable of generating responses directed against syngeneic as well as allogeneic class Ia molecules in vitro. Thus, class Ia-deficient animals have a CD8+ T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/author | "Seaman M.S."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/author | "Lindahl K.F."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/author | "Forman J."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/author | "Perarnau B."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/pages | "5429-5436"xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/title | "Response to Listeria monocytogenes in mice lacking MHC class Ia molecules."xsd:string |
| http://purl.uniprot.org/citations/10228021 | http://purl.uniprot.org/core/volume | "162"xsd:string |
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