| http://purl.uniprot.org/citations/10228155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10228155 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-catenin plays an essential role in the Wingless/Wnt signaling cascade and is a component of the cadherin cell adhesion complex. Deregulation of beta-catenin accumulation as a result of mutations in adenomatous polyposis coli (APC) tumor suppressor protein is believed to initiate colorectal neoplasia. beta-catenin levels are regulated by the ubiquitin-dependent proteolysis system and beta-catenin ubiquitination is preceded by phosphorylation of its N-terminal region by the glycogen synthase kinase-3beta (GSK-3beta)/Axin kinase complex. Here we show that FWD1 (the mouse homologue of Slimb/betaTrCP), an F-box/WD40-repeat protein, specifically formed a multi-molecular complex with beta-catenin, Axin, GSK-3beta and APC. Mutations at the signal-induced phosphorylation site of beta-catenin inhibited its association with FWD1. FWD1 facilitated ubiquitination and promoted degradation of beta-catenin, resulting in reduced cytoplasmic beta-catenin levels. In contrast, a dominant-negative mutant form of FWD1 inhibited the ubiquitination process and stabilized beta-catenin. These results suggest that the Skp1/Cullin/F-box protein FWD1 (SCFFWD1)-ubiquitin ligase complex is involved in beta-catenin ubiquitination and that FWD1 serves as an intracellular receptor for phosphorylated beta-catenin. FWD1 also links the phosphorylation machinery to the ubiquitin-proteasome pathway to ensure prompt and efficient proteolysis of beta-catenin in response to external signals. SCFFWD1 may be critical for tumor development and suppression through regulation of beta-catenin protein stability."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.9.2401"xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Kitagawa M."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Ishida N."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Nakayama K.'"xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Hattori K."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Shirane M."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/author | "Nakamichi I."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/pages | "2401-2410"xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/title | "An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10228155 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10228155 |
| http://purl.uniprot.org/citations/10228155 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10228155 |
| http://purl.uniprot.org/uniprot/O70239#attribution-D41B8B0B831542BB0C6BD085BBA059A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10228155 |
| http://purl.uniprot.org/uniprot/O70239#attribution-F65A9F10BBEFAA4D73BAECFA22ED9723 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10228155 |
| http://purl.uniprot.org/uniprot/Q3ULA2#attribution-F65A9F10BBEFAA4D73BAECFA22ED9723 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10228155 |
| http://purl.uniprot.org/uniprot/P18266#attribution-F65A9F10BBEFAA4D73BAECFA22ED9723 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10228155 |
| http://purl.uniprot.org/uniprot/#_A0A0G2KB98-mappedCitation-10228155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10228155 |