| http://purl.uniprot.org/citations/10229092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10229092 | http://www.w3.org/2000/01/rdf-schema#comment | "Single H2Kb, H2Db and double H2KbDb homozygous knockout (KO) mice were generated and their peripheral CD8+ T cell repertoires compared to that of C57BL/6 (B6) mice. Limited (10-20%, H2Db), substantial (30-50%, H2Kb) and profound (90%, H2KbDb) reduction of peripheral CD8+ T cells was observed in KO mice, without Vbeta diversity alteration. Classical class Ia molecules therefore ensure most but not all of the peripheral CD8+ T cell repertoire education. As expected, H2Kb but also H2Db KO mice developed choriomeningitis following intracranial infection by lymphocytic choriomeningitis virus with the same kinetics, lethality and CD8+ cell implication as wild-type B6 mice. By contrast, H2KbDb (class Ia-Ib+) KO mice survived. Choriomeningitis of H2Db KO mice was linked to the development of a subdominant (in normal B6 mice) H2Kb-restricted cytotoxic T lymphocyte response. Mice expressing a restricted set of histocompatibility class I molecules should represent useful tools to evaluate the immunological potentials of individual MHC class I molecules."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1521-4141(199904)29:04<1243::aid-immu1243>3.0.co;2-a"xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Smith A.G."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Gairin J.E."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Ong H."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Ure J.M."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Reina San Martin B."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Saron M.F."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Bervas N."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Perarnau B."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/author | "Soloski M.J."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/pages | "1243-1252"xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/title | "Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses."xsd:string |
| http://purl.uniprot.org/citations/10229092 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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