| http://purl.uniprot.org/citations/10229200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10229200 | http://www.w3.org/2000/01/rdf-schema#comment | "dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expression, function and interactions of dMax. RT/PCR analyses detected dmax mRNA in multiple tissues of the developing, newborn and adult mouse. Functionally, dMax reduced the ability of c-Myc to cooperate with the progression factor A-Myb to promote S phase entry of quiescent smooth muscle cells. In contrast, dMax failed to ablate inhibition of initiator element (Inr)-mediated transcription by c-Myc in Jurkat T cells. In in vitro protein:protein association assays, dMax interacted with c-Myc, N-Myc, L-Myc, Mad1, Mxi1, Mad3 and Mad4, but not with itself or wild-type Max. These interactions required an intact leucine zipper. Inhibition of E-box-mediated transactivation by induction of dMax overexpression resulted in apoptosis of WEHI 231 B cells. Thus, dMax is a widely expressed, naturally occurring protein, with the capacity to bind most members of the Myc/Max superfamily; dMax has little effect on Inr-mediated repression by c-Myc, but can significantly decrease E-box-mediated events promoting proliferation and cell survival."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202611"xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Chin L."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "DePinho R.A."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Sonenshein G.E."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Arsura M."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Bellas R.E."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "FitzGerald M.J."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/author | "Mann K.K."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/pages | "2489-2498"xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/title | "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc."xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10229200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10229200 |
| http://purl.uniprot.org/citations/10229200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10229200 |
| http://purl.uniprot.org/uniprot/Q99N42#attribution-5AFBEEFA4880F3B54EBA213898B9D3D4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10229200 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF6-mappedCitation-10229200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10229200 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW68-mappedCitation-10229200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10229200 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-10229200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10229200 |
| http://purl.uniprot.org/uniprot/#_A0A991B922-mappedCitation-10229200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10229200 |
| http://purl.uniprot.org/uniprot/#_A0A991CU09-mappedCitation-10229200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10229200 |