| http://purl.uniprot.org/citations/10230406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10230406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10230406 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the transcription factor NF-kappa B in response to proinflammatory stimuli requires the phosphorylation-triggered and ubiquitin-dependent degradation of the NF-kappa B inhibitor, I kappa B alpha. Here, we show the in vitro reconstitution of the phosphorylation-dependent ubiquitination of I kappa B alpha with purified components. ROC1, a novel SCF-associated protein, is recruited by cullin 1 to form a quatemary SCFHOS-ROC1 holenzyme (with Skp1 and the beta-TRCP homolog HOS). SCFHOS-ROC1 binds IKK beta-phosphorylated I kappa B alpha and catalyzes its ubiquitination in the presence of ubiquitin, E1, and Cdc34. ROC1 plays a unique role in the ubiquitination reaction by heterodimerizing with cullin 1 to catalyze ubiquitin polymerization."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80481-5"xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80481-5"xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Tan P."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Tan P."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Gomez C."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Gomez C."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Fuchs S.Y."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Fuchs S.Y."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Ronai Z."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Ronai Z."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Pan Z.-Q."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/author | "Pan Z.-Q."xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/pages | "527-533"xsd:string |
| http://purl.uniprot.org/citations/10230406 | http://purl.uniprot.org/core/pages | "527-533"xsd:string |