| http://purl.uniprot.org/citations/10319874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10319874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10319874 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability. Post-mortem examination shows loss of neurons and Lewy bodies, which are cytoplasmic eosinophilic inclusions, in the substantia nigra and other brain regions. A few families have PD caused by mutations (A53T or A30P) in the gene SNCA (encoding alpha-synuclein). Alpha-synuclein is present in Lewy bodies of patients with sporadic PD, suggesting that alpha-synuclein may be involved in the pathogenesis of PD. It is unknown how alpha-synuclein contributes to the cellular and biochemical mechanisms of PD, and its normal functions and biochemical properties are poorly understood. To determine the protein-interaction partners of alpha-synuclein, we performed a yeast two-hybrid screen. We identified a novel interacting protein, which we term synphilin-1 (encoded by the gene SNCAIP). We found that alpha-synuclein interacts in vivo with synphilin-1 in neurons. Co-transfection of both proteins (but not control proteins) in HEK 293 cells yields cytoplasmic eosinophilic inclusions."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.org/dc/terms/identifier | "doi:10.1038/8820"xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.org/dc/terms/identifier | "doi:10.1038/8820"xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Kleiderlein J.J."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Kleiderlein J.J."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Margolis R.L."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Margolis R.L."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Ross C.A."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Ross C.A."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Sharp A.H."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Sharp A.H."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Engelender S."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Engelender S."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Lanahan A."xsd:string |
| http://purl.uniprot.org/citations/10319874 | http://purl.uniprot.org/core/author | "Lanahan A."xsd:string |