| http://purl.uniprot.org/citations/10321728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10321728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10321728 | http://www.w3.org/2000/01/rdf-schema#comment | "SCF E3 ubiquitin ligases mediate ubiquitination and proteasome-dependent degradation of phosphorylated substrates. We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb/h betaTrCP. Being a part of SCF complex with Skp1 and Cullin1, HOS specifically interacted with the phosphorylated IkappaB and beta-catenin, targeting these proteins for proteasome-dependent degradation in vivo. This targeting required Cullin1 as expression of a mutant Cullin1 abrogated the degradation of IkappaB and of beta-catenin. Mutant HOS which lacks the F-box blocked TNF alpha-induced degradation of IkappaB as well as GSK3beta-mediated degradation of beta-catenin. This mutant also inhibited NF-kappaB transactivation and increased the beta-catenin-dependent transcription activity of Tcf. These results demonstrate that SCF(HOS) E3 ubiquitin ligase regulate both NF-kappaB and beta-catenin signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202760"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202760"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Fuchs S.Y."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Fuchs S.Y."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Ronai Z."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Ronai Z."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Pan Z.Q."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/author | "Pan Z.Q."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/pages | "2039-2046"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/pages | "2039-2046"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/title | "HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/title | "HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10321728 | http://purl.uniprot.org/core/volume | "18"xsd:string |