| http://purl.uniprot.org/citations/10329382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329382 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) can be phosphorylated at Thr654, Ser655, and Thr668 (APP695 isoform numbering). Previous studies demonstrated that Ser655 of APP was phosphorylated by protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMKII) in vitro and by unidentified protein kinase(s) in vivo. We report here the characterization of a novel protein kinase (designated APP kinase I) which phosphorylates Ser655 of APP. APP kinase I was partially purified over 7,000-fold from rat brain and identified as a approximately 43 kDa protein that is distinct from a number of known protein kinases, including PKC and extracellular signal-regulated kinases (ERKs). The identification of a novel protein kinase that phosphorylates Ser655 will hopefully contribute to our understanding of the metabolism and/or function of APP in the pathogenesis of Alzheimer's disease (AD)."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0637"xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0637"xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Czernik A.J."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Czernik A.J."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Horiuchi A."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Horiuchi A."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Isohara T."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Isohara T."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Nairn A.C."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Nairn A.C."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Uno I."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/author | "Uno I."xsd:string |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10329382 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |