| http://purl.uniprot.org/citations/10329413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329413 | http://www.w3.org/2000/01/rdf-schema#comment | "The large subunit of RFC (RFC p140) has been suggested to be associated with the 3'-end of elongating DNA primer and to recruit proliferating cell nuclear antigen (PCNA) onto DNA polymerase delta. Previously, we isolated a cDNA clone encoding a DNA-binding domain of RFC p140 as a telomeric repeat (TTAGGG)n binding protein. This domain was shown to have a specific affinity for the 5'-phosphate ends of a telomere repeat sequence. In order to investigate the structure and function of RFC p140, we constructed the full-length recombinant RFC p140 as well as N-and/or C-terminal deleted mutants and analyzed their telomere-binding activities. South-Western blot and gel mobility shift analyses revealed that deletion of the N-but not the C-terminal region enhances recognition of the telomeric repeat sequence and 5'-phosphate ends, suggesting the negative effect of the N-terminal region of the RFC p140 binding to the telomeric repeat. On the other hand, the C-terminal truncated RFC inhibits the telomerase activity more than the N-terminal-deleted and full-length RFC p140. The inhibitory effect of RFC p140 on telomerase activity is completely diminished by both terminal deletions. Thus, a certain interaction of the N- and C-terminal regions is considered to be required for RFC p140 to suppress telomerase activity. Taken together, these results suggest that both telomeric repeat-binding and telomerase inhibitory activities of RFC p140 are finely regulated by the intrinsic N- and C-terminal regions."xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0589"xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/author | "Uchiumi F."xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/author | "Tanuma S.i."xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/pages | "482-489"xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/title | "Characterization of telomere-binding activity of replication factor C large subunit p140."xsd:string |
| http://purl.uniprot.org/citations/10329413 | http://purl.uniprot.org/core/volume | "258"xsd:string |
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