| http://purl.uniprot.org/citations/10329629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329629 | http://www.w3.org/2000/01/rdf-schema#comment | "In eukaryotes, DNA is packaged into chromatin, a compact structure that must be disrupted when genes are transcribed by RNA polymerase II. For transcription to take place, chromatin is remodeled via nucleosome disruption or displacement, a fundamental transcriptional regulatory mechanism in eukaryotic organisms. Here we show that the yeast chromatin-remodeling complex, RSC (remodels the structure of chromatin), isolated on the basis of homology to the SWI/SNF complex, is required for proper transcriptional regulation and nucleosome positioning in the highly inducible CHA1 promoter. In the absence of Sth1p/Nps1p (a homolog of Swi2p/Snf2p) or of Swh3p (a homolog of Swi3p), expression of CHA1 in non-induced cells is increased to a level comparable with that of fully induced cells. Furthermore, in non-induced cells depleted for Sth1p/Nps1p or Swh3p, a nucleosome positioned over the TATA box of the CHA1 promoter is disrupted, an architectural change normally only observed during transcriptional induction. In addition, deletion of the gene-specific activator Cha4p did not affect derepression of CHA1 in cells depleted for Swh3p. Thus, CHA1 constitutes a target for the RSC complex, and we propose that RSC is essential for maintaining a repressive chromatin structure at the CHA1 promoter."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.10.2836"xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.10.2836"xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/author | "Holmberg S."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/author | "Holmberg S."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/author | "Moreira J.M.A."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/author | "Moreira J.M.A."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/pages | "2836-2844"xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/pages | "2836-2844"xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/title | "Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/title | "Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC."xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10329629 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10329629 |
| http://purl.uniprot.org/citations/10329629 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10329629 |
| http://purl.uniprot.org/citations/10329629 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10329629 |
| http://purl.uniprot.org/citations/10329629 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10329629 |
| http://purl.uniprot.org/uniprot/Q06168 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10329629 |
| http://purl.uniprot.org/uniprot/Q12406 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10329629 |