| http://purl.uniprot.org/citations/10329666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10329666 | http://www.w3.org/2000/01/rdf-schema#comment | "Tvl-1 is a 269-amino acid ankyrin repeat protein expressed primarily in thymus, lung, and testes that was identified by screening a murine T-cell two-hybrid cDNA library for proteins that associate with the serine-threonine kinase Raf-1. The interaction of Tvl-1 with Raf-1 was confirmed by co-immunoprecipitation of the two proteins from COS-1 cells transiently transfected with Tvl-1 and Raf-1 expression constructs as well as by co-immunoprecipitation of the endogenous proteins from CV-1 and NB2 cells. Tvl-1 interacts with Raf-1 via its carboxyl-terminal ankyrin repeat domain. The same domain also mediates Tvl-1 homodimerization. Tvl-1 was detected by immunofluorescence in both the cytoplasm and the nucleus suggesting that in addition to Raf-1 it may also interact with nuclear proteins. Activated Raf-1 phosphorylates Tvl-1 both in vitro and in vivo. In baculovirus-infected Sf9 insect cells, Tvl-1 potentiates the activation of Raf-1 by Src and Ras while in COS-1 cells it potentiates the activation of Raf-1 by EGF. These data suggest that Tvl-1 is both a target as well as a regulator of Raf-1. The human homologue of Tvl-1 maps to chromosome 19p12, upstream of MEF2B with the two genes in a head to head arrangement."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.21.14706"xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.21.14706"xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Golemis E.A."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Golemis E.A."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "McMahon C."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "McMahon C."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Lin J.-H."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Lin J.-H."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Brent R."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Brent R."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Bear S.E."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Bear S.E."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Makris A."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Makris A."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Patriotis C."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Patriotis C."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Prasad V.R."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/author | "Prasad V.R."xsd:string |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10329666 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |