http://purl.uniprot.org/citations/10329788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10329788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10329788 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytochrome P450sca-2 from Streptomyces carbophilus catalyzes the hydroxylation of ML-236B sodium salt to pravastatin sodium, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl-coenzymeA (HMG-CoA) reductase. HMG-CoA reductase is a key enzyme in cholesterol biosynthesis. Crystals of the protein were obtained by the vapour-diffusion method, using ammonium sulfate as a precipitant. The crystals belong to the trigonal space group P3121 (or its enantiomorph, P3221) with unit-cell dimensions a = 103.5, c = 79.8 A. Assuming the presence of one molecule in the asymmetric unit, the calculated value of Vm is 2.68 A3 Da-1. A native data set was collected to a resolution of 2.2 A."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444999003716"xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444999003716"xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Hata T."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Hata T."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Kagasaki T."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Kagasaki T."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Matsuoka T."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Matsuoka T."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Serizawa N."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Serizawa N."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Watanabe I."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/author | "Watanabe I."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/pages | "1209-1211"xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/pages | "1209-1211"xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/title | "Crystallization and preliminary X-ray diffraction analysis of cytochrome P450sca-2 from Streptomyces carbophilus involved in production of pravastatin sodium, a tissue-selective inhibitor of HMG-CoA reductase."xsd:string |
http://purl.uniprot.org/citations/10329788 | http://purl.uniprot.org/core/title | "Crystallization and preliminary X-ray diffraction analysis of cytochrome P450sca-2 from Streptomyces carbophilus involved in production of pravastatin sodium, a tissue-selective inhibitor of HMG-CoA reductase."xsd:string |