| http://purl.uniprot.org/citations/10330043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10330043 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine whether atrial natriuretic peptide (ANP) plays a physiological role in modulating pulmonary hypertensive responses, we studied mice with gene-targeted disruption of the ANP gene under normoxic and chronically hypoxic conditions. Right ventricular peak pressure (RVPP), right ventricle weight- and left ventricle plus septum weight-to-body weight ratios [RV/BW and (LV+S)/BW, respectively], and muscularization of pulmonary vessels were measured in wild-type mice (+/+) and in mice heterozygous (+/-) and homozygous (-/-) for a disrupted proANP gene after 3 wk of normoxia or hypobaric hypoxia (0.5 atm). Under normoxic conditions, homozygous mutants had higher RVPP (22 +/-2 vs. 15 +/- 1 mmHg; P < 0.05) than wild-type mice and greater RV/BW (1.22 +/-0.08 vs. 0.94 +/- 0.07 and 0.76 +/- 0.04 mg/g; P < 0.05) and (LV+S)/BW (4.74 +/-0. 42 vs. 3.53 +/- 0.14 and 3.18 +/-0.18 mg/g; P < 0.05) than heterozygous or wild-type mice, respectively. Three weeks of hypoxia increased RVPP in heterozygous and wild-type mice and increased RV/BW and RV/(LV+S) in all genotypes compared with their normoxic control animals but had no effect on (LV+S)/BW. After 3 wk of hypoxia, homozygous mutants had higher RVPP (29 +/- 3 vs. 23 +/- 1 and 22 +/-2 mmHg; P < 0.05), RV/BW (2.03 +/- 0.14 vs. 1.46 +/- 0.04 and 1.33 +/-0.08 mg/g; P < 0.05), and (LV+S)/BW (4.76 +/- 0.23 vs. 3.82 +/-0.09 and 3.44 +/-0.14 mg/g; P < 0.05) than heterozygous or wild-type mice, respectively. The percent muscularization of peripheral pulmonary vessels was greater in homozygous mutants than that in heterozygous or wild-type mice under both normoxic and hypoxic conditions. We conclude that endogenous ANP plays a physiological role in modulating pulmonary arterial pressure, cardiac hypertrophy, and pulmonary vascular remodeling under normoxic and hypoxic conditions."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.1999.276.5.l868"xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/author | "Smithies O."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/author | "Warburton R.R."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/author | "Hill N.S."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/author | "Klinger J.R."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/author | "Pietras L.A."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/author | "Swift R."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/name | "Am J Physiol"xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/pages | "L868-74"xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/title | "Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice."xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/10330043 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10330043 |
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| http://purl.uniprot.org/uniprot/#_P05125-mappedCitation-10330043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330043 |
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