| http://purl.uniprot.org/citations/10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10330148 | http://www.w3.org/2000/01/rdf-schema#comment | "Colony-stimulating factor 1 (CSF-1) triggers the activation of intracellular proteins in macrophages through selective assembly of signalling complexes. The separation of multimeric complexes of the CSF-1 receptor (CSF-1R) by anion-exchange chromatography enabled the enrichment of low-stoichiometry complexes. A significant proportion of the receptor in CSF-1-stimulated cells that neither possessed detectable tyrosine kinase activity nor formed complexes was separated from the receptor pool displaying autokinase activity that formed chromatographically distinct multimeric complexes. A small pool of CSF-1R formed a multimeric complex with phosphatidylinositol-3 kinase (PI-3 kinase), SHP-1, Grb2, Shc, c-Src, Cbl, and a significant number of tyrosine-phosphorylated proteins in CSF-1-stimulated cells. The complex showed a considerable amount of CSF-1R complex-associated kinase activity. A detectable level of the complex was also present in untreated cells. PI-3 kinase in the multimeric complex displayed low lipid kinase activity despite the association with several proteins. The major pool of activated CSF-1R formed transient multimeric complexes with distinctly different tyrosine-phosphorylated proteins, which included STAT3 but also PI-3 kinase, Shc, SHP-1, and Grb2. A significant level of lipid kinase activity was detected in PI-3 kinase in the latter complexes. The different specific enzyme activities of PI-3 kinase in these complexes support the notion that the activity of PI-3 kinase is modulated by its association with CSF-1R and other associated cellular proteins. Specific structural proteins associated with the separate CSF-1R multimeric complexes upon CSF-1 stimulation and the presence of the distinct pools of the CSF-1R were dependent on the integrity of the microtubular network."xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.19.6.4079"xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/author | "Hamilton J.A."xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/author | "Kanagasundaram V."xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/author | "Jaworowski A."xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/author | "Byrne R."xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/pages | "4079-4092"xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/title | "Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages."xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10330148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10330148 |
| http://purl.uniprot.org/citations/10330148 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10330148 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P06241-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P27986-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_O75791-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P42338-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_O15357-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P16885-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P07947-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P07948-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P08631-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |
| http://purl.uniprot.org/uniprot/#_P09603-mappedCitation-10330148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10330148 |