| http://purl.uniprot.org/citations/10330270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10330270 | http://www.w3.org/2000/01/rdf-schema#comment | "Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region at 16.5-17.0 d.p.c. (step II), and entry of CD3+ and B220+ lymphocytes just before birth (step III). PP formation of both Il7ra-/- and Lta-/-mice is impaired from step I, suggesting involvement of the two molecules at the same timing in PP organogenesis. Expression of lymphotoxin (LT) alpha and LTbeta in IL-7 receptor (IL-7R) alpha+ cells in the intestine indicates that defects of Il7ra-/- and Lta-/-mice are due to functional inability of IL-7Ralpha+ cells in the induction of PP anlage. Blocking of IL-7Ralpha function by a single injection of the antagonistic mAb in 15.5 d.p.c. embryos suppressed appearance of VCAM-1(+) spots and expression of LTalpha and LTbeta in the intestine, which eventually resulted in mice without PP but are otherwise normal. Intestinal IL-7Ralpha+ cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2-/-mice. These results implicate IL-7Ralpha+ CD3(-) cells as the direct inducer of the organizing center of PP."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/11.5.643"xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Adachi S."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Nishikawa S."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Maki K."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Ikuta K."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Honda K."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Shinkura R."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/author | "Nishikawa S.I."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/pages | "643-655"xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/title | "IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches."xsd:string |
| http://purl.uniprot.org/citations/10330270 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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