| http://purl.uniprot.org/citations/10339552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10339552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10339552 | http://www.w3.org/2000/01/rdf-schema#comment | "Exonic splicing enhancer (ESE) sequences are important for the recognition of splice sites in pre-mRNA. These sequences are bound by specific serine-arginine (SR) repeat proteins that promote the assembly of splicing complexes at adjacent splice sites. We have recently identified a splicing "coactivator," SRm160/300, which contains SRm160 (the SR nuclear matrix protein of 160 kDa) and a 300-kDa nuclear matrix antigen. In the present study, we show that SRm160/300 is required for a purine-rich ESE to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene. The association of SRm160/300 and U2 small nuclear ribonucleoprotein particle (snRNP) with this pre-mRNA requires both U1 snRNP and factors bound to the ESE. Independently of pre-mRNA, SRm160/300 specifically interacts with U2 snRNP and with a human homolog of the Drosophila alternative splicing regulator Transformer 2, which binds to purine-rich ESEs. The results suggest a model for ESE function in which the SRm160/300 splicing coactivator promotes critical interactions between ESE-bound "activators" and the snRNP machinery of the spliceosome."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.11.6125"xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.11.6125"xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Sharp P.A."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Sharp P.A."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Blencowe B.J."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Blencowe B.J."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Eldridge A.G."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/author | "Eldridge A.G."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/pages | "6125-6130"xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/pages | "6125-6130"xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/title | "The SRm160/300 splicing coactivator is required for exon-enhancer function."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/title | "The SRm160/300 splicing coactivator is required for exon-enhancer function."xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10339552 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10339552 |
| http://purl.uniprot.org/citations/10339552 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10339552 |