| http://purl.uniprot.org/citations/10341223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10341223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10341223 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein assembly at the postsynaptic density (PSD) of neuronal synapses is mediated in part by protein interactions with PSD-95/discs large/zona occludens-1 (PDZ) motifs. Here, we identify MALS-1, -2, -3, a family of small synaptic proteins containing little more than a single PDZ domain. MALS-1, -2, and -3 are mammalian homologs LIN-7, a Caenorhabditis elegans protein essential for vulval development. In contrast to functions for LIN-7 in epithelial cells, MALS-1 and -2 are selectively expressed in specific neuronal populations in brain and are enriched in PSD fractions. In cultured hippocampal neurons, MALS proteins are clustered together with PSD-95 and NMDA type glutamate receptors, consistent with a postsynaptic localization for MALS proteins. Immunoprecipitation and affinity chromatography studies readily identify association of MALS with PSD-95 and an NMDA receptor subunit. The PDZ domain of MALS selectively binds to peptides terminating in E-T/S-R/X-V/I/L, which corresponds to the C terminus of NMDA type 2 receptors and numerous other ion channels at the PSD. This work suggests a role for MALS proteins in regulating recruitment of neurotransmitter receptors to the PSD."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-11-04189.1999"xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-11-04189.1999"xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Bredt D.S."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Bredt D.S."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Jo K."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Jo K."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Derin R."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/author | "Derin R."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/pages | "4189-4199"xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/pages | "4189-4199"xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/title | "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/title | "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex."xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10341223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10341223 |
| http://purl.uniprot.org/citations/10341223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10341223 |