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http://purl.uniprot.org/citations/10352232http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10352232http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10352232http://www.w3.org/2000/01/rdf-schema#comment"Two cDNAs encoding PAK kinases were isolated from a mouse embryo library by screening with a PCR-generated probe derived from the kinase domain of a rat PAK kinase. These cDNAs, designated PAK-1 and PAK-3, encode mouse PAK kinases of 545 and 544 amino acids, respectively. Both proteins possess an N-terminal Cdc42/Rac interacting binding domain (CRIB) and a C-terminal serine/threonine kinase domain. Comparison of the two mouse PAK kinases revealed that the proteins show 87% amino acid identity. Northern analysis of a multiple mouse tissue blot with a PAK-1 probe detected a 3.0kb transcript that was almost exclusively expressed in the brain and spinal cord compared to other tissues such as lung, liver and kidney. A similar pattern of central nervous system tissue expression of PAK-3 transcripts of 3.6 and 8kb was also observed. Analysis of two multilocus genetic crosses localized Pak1 and Pak3 to a position on chromosome 7 and X, respectively. The high level of PAK-1 and PAK-3 kinase expression in the mouse brain and spinal cord suggests a potentially important role for these kinases in the control of the cellular architecture and/or signaling in the central nervous system."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.org/dc/terms/identifier"doi:10.1016/s0378-1119(99)00110-9"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.org/dc/terms/identifier"doi:10.1016/s0378-1119(99)00110-9"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Kozak C.A."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Kozak C.A."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Hall A."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Hall A."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Burbelo P.D."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Burbelo P.D."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Pirone D.M."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Pirone D.M."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Finegold A.A."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/author"Finegold A.A."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/pages"209-215"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/pages"209-215"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/title"Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/title"Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes."xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/volume"232"xsd:string
http://purl.uniprot.org/citations/10352232http://purl.uniprot.org/core/volume"232"xsd:string