| http://purl.uniprot.org/citations/10353611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10353611 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear factor kappaB, a transcription factor regulating the expression of multiple genes including genes essential for cell cycle control, is found in most cells in a dormant state in the cytoplasm bound to the inhibitory family I kappaB via an ankyrin repeat domain. Stimulation of cells with a variety of inducers inactivates I kappaB proteins. The active dimeric NF-kappaB complex, often composed of 50- and 65-kilodalton subunits of the Rel family, translocates into the nucleus, where the NF-kappaBp65 subunit stimulates transcription. Here we report that a family of proteins containing ankyrin repeats, the inhibitors of Cdk4 (INK4) is able to bind NF-kappaBp65. The association of p16INK4 with NF-kappaBp65 is considerable in HeLa- or 293 cells, if the NF-kappaB inhibitor I kappaB alpha is degraded in response to TNFalpha stimulation. Overexpression of INK4 molecules suppresses the transactivational ability of NF-kappaB significantly. In contrast to INK4 proteins, the cell cycle inhibitor p27 enhances NF-kappaB transactivation activity. Thus, the effect of INK4 proteins on NF-kappaB function possibly modifies NF-kappaB mediated transcriptional activation of cell cycle associated factors."xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202617"xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/author | "Wolff B."xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/author | "Naumann M."xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/pages | "2663-2666"xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/title | "INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10353611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10353611 |
| http://purl.uniprot.org/citations/10353611 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10353611 |
| http://purl.uniprot.org/uniprot/P42771#attribution-F79FBCC4FE84121DB08F38426E86CBCB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10353611 |