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http://purl.uniprot.org/citations/10356395http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10356395http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10356395http://www.w3.org/2000/01/rdf-schema#comment"We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.org/dc/terms/identifier"doi:10.1126/science.284.5420.1664"xsd:string
http://purl.uniprot.org/citations/10356395http://purl.org/dc/terms/identifier"doi:10.1126/science.284.5420.1664"xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Liu R.-Q."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Liu R.-Q."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Yang F."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Yang F."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Bruckner R."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Bruckner R."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Murphy K."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Murphy K."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Itoh Y."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Itoh Y."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Burn T.C."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Burn T.C."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Hollis G.F."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Hollis G.F."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Copeland R.A."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Copeland R.A."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Nagase H."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Nagase H."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Hollis J.M."xsd:string
http://purl.uniprot.org/citations/10356395http://purl.uniprot.org/core/author"Hollis J.M."xsd:string