| http://purl.uniprot.org/citations/10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10357794 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumour formation may involve interactions between genetic factors and environmental carcinogens. Adenoma formation in APCMin/+ mice is associated homozygous adenomatous polyposis coli (APC) gene mutation, but the effects on carcinogen susceptibility are unknown. This study tests the hypothesis that APCMin/+ adenoma formation is accompanied by changes in metabolic proficiency and carcinogen susceptibility. Cytochrome P450 (CYP)1A1/1A2, glutathione S-transferase (GST)alpha, mu and pi classes and DNA adduct formation were assayed in adenomas and uninvolved mucosa from APCMin/+ mice, before and after benzo[a]pyrene (B[a]P) treatment. In untreated adenomas and mucosa, CYP1A1/1A2 and B[a]P-DNA adducts were undetected but GSTalpha, mu and pi class enzymes were constitutively expressed. In adenomas, B[a]P only induced CYP1A1/1A2 to low level while GSTalpha and pi class enzymes were unaffected. A GST mu band which was absent from mucosa, was induced in adenomas. In mucosa, B[a]P induced CYP1A1/1A2 and GSTalpha and pi, to high levels. B[a]P-DNA adduct levels were 56 +/- 15/10(8) nucleotides (median +/- SE) in adenomas versus 89 +/-19/10(8) nucleotides in mucosa (P < 0.0001). APCMin adenomas show reduced bioactivation capacity and sustain less DNA damage from B[a]P exposure, than APCMin uninvolved mucosa. These properties could influence mutagenesis and subsequent neoplastic transformation of adenomas."xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/20.6.1097"xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/author | "Campbell F.C."xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/author | "Sattar A."xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/author | "Phillips D.H."xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/author | "Hewer A."xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/pages | "1097-1101"xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/title | "Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa."xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10357794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10357794 |
| http://purl.uniprot.org/citations/10357794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10357794 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_E9Q4H1-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_F6Q4R2-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_Q8BRD8-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_Q3UQT2-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_Q8BNP7-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_Q61315-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |
| http://purl.uniprot.org/uniprot/#_Q8C493-mappedCitation-10357794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10357794 |