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| http://purl.uniprot.org/citations/10358768 | http://www.w3.org/2000/01/rdf-schema#comment | "In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma 2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma 2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future."xsd:string |
| http://purl.uniprot.org/citations/10358768 | http://purl.org/dc/terms/identifier | "doi:10.1146/annurev.immunol.17.1.555"xsd:string |
| http://purl.uniprot.org/citations/10358768 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/10358768 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10358768 | http://purl.uniprot.org/core/name | "Annu Rev Immunol"xsd:string |
| http://purl.uniprot.org/citations/10358768 | http://purl.uniprot.org/core/pages | "555-592"xsd:string |
| http://purl.uniprot.org/citations/10358768 | http://purl.uniprot.org/core/title | "Genetic analysis of B cell antigen receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/10358768 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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