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http://purl.uniprot.org/citations/10359803http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10359803http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10359803http://www.w3.org/2000/01/rdf-schema#comment"P element insertion is essentially random at the scale of the genome. However, P elements containing regulatory sequences from Drosophila engrailed and polyhomeotic genes and from the Bithorax and Antennapedia complexes show some insertional specificity by frequently inserting near the parent gene (homing) and/or near genes containing Polycomb group response elements (preferential insertion). This phenomenon is thought to be mediated by Polycomb group proteins. In this report, we describe a case of homing of P elements containing regulatory sequences of the linotte gene. This homing occurs with high frequency (up to 20% of the lines) and high precision (inserted into a region of <1 kilobase). We present evidence showing that it is not mediated by Polycomb group proteins but by a new, as yet unknown, mechanism. We also suggest that P element homing could be a more frequent phenomenon than generally assumed and that it could become a powerful tool of Drosophila reverse genetics, for which there is no other described gene targeting technique."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.org/dc/terms/identifier"doi:10.1073/pnas.96.12.6856"xsd:string
http://purl.uniprot.org/citations/10359803http://purl.org/dc/terms/identifier"doi:10.1073/pnas.96.12.6856"xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/author"Taillebourg E."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/author"Taillebourg E."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/author"Dura J.-M."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/author"Dura J.-M."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/pages"6856-6861"xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/pages"6856-6861"xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/title"A novel mechanism for P element homing in Drosophila."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/title"A novel mechanism for P element homing in Drosophila."xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/10359803http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/10359803http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10359803
http://purl.uniprot.org/citations/10359803http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10359803
http://purl.uniprot.org/citations/10359803http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10359803
http://purl.uniprot.org/citations/10359803http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10359803
http://purl.uniprot.org/uniprot/Q27324http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10359803
http://purl.uniprot.org/uniprot/#_Q27324-citation-10359803http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10359803