| http://purl.uniprot.org/citations/10359807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10359807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10359807 | http://www.w3.org/2000/01/rdf-schema#comment | "Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of gamma delta T cells expressing the variable region Vdelta1. This functional association has been found to be limited to intestinal epithelium, where these T cells are prevalent and where MICA and, presumably, MICB are mainly expressed. However, increased frequencies of Vdelta1 gamma delta T cells have been observed in various epithelial tumors; moreover, MICA/B are expressed on diverse cultured epithelial tumor cells. With freshly isolated tumor specimens, expression of MICA/B was documented in many, but not all, carcinomas of the lung, breast, kidney, ovary, prostate, and colon. In tumors that were positive for MICA/B, the frequencies of Vdelta1 gamma delta T cells were significantly higher than in those that were negative. Vdelta1 gamma delta T cell lines and clones derived from different tumors recognized MICA/B on autologous and heterologous tumor cells. In accord with previous evidence, no constraints were observed in these interactions, such as those imposed by specific peptide ligands. Thus, MICA/B are tumor-associated antigens that can be recognized, in an apparently unconditional manner, by a subset of tumor-infiltrating gamma delta T cells. These results raise the possibility that an induced expression of MICA/B, by conditions that may be related to tumor homeostasis and growth, could play a role in immune responses against tumors."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.12.6879"xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.12.6879"xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Bauer S."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Bauer S."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Spies T."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Spies T."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Grabstein K.H."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Grabstein K.H."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Secrist H."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Secrist H."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Groh V."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Groh V."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Rhinehart R."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/author | "Rhinehart R."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/pages | "6879-6884"xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/pages | "6879-6884"xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/title | "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."xsd:string |
| http://purl.uniprot.org/citations/10359807 | http://purl.uniprot.org/core/title | "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."xsd:string |