| http://purl.uniprot.org/citations/10359808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10359808 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) are expressed by T cells and macrophages, but there is a paucity of evidence for their role in immune responses. We have studied mice with deficiencies of stromelysin-1 (MMP-3) or gelatinase B (MMP-9) in a dinitrofluorobenzene (DNFB)-induced model of contact hypersensitivity (CHS). Stromelysin-1-deficient mice showed a markedly impaired CHS response to topical DNFB, although they responded normally to cutaneously applied phenol, an acute irritant. Lymphocytes from lymph nodes of DNFB-sensitized stromelysin-1-deficient mice did not proliferate in response to specific soluble antigen dinitrobenzenesulfonic acid, but did proliferate identically to lymph node lymphocytes from wild-type mice when presented with the mitogen Con A. An intradermal injection of stromelysin-1 immediately before DNFB sensitization rescued the impaired CHS response to DNFB in stromelysin-1-deficient mice. Unlike stromelysin-1-deficient mice, gelatinase B-deficient mice exhibited a CHS response comparable to wild-type controls at 1 day postchallenge, but the response persisted beyond 7 days in contrast to the complete resolution observed in wild-type mice by 7 days. However, gelatinase B-deficient mice had a normal rate of resolution of acute inflammation elicited by cutaneous phenol. Gelatinase B-deficient mice failed to show IL-10 production at the site of CHS, an essential feature of resolution in control mice. These results indicate that stromelysin-1 and gelatinase B serve important functions in CHS. Stromelysin-1 is required for initiation of the response, whereas gelatinase B plays a critical role in its resolution."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.12.6885"xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/author | "Qin X."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/author | "Ferguson T.A."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/author | "Mudgett J.S."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/author | "Senior R.M."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/author | "Welgus H.G."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/pages | "6885-6889"xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response."xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10359808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10359808 |
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