| http://purl.uniprot.org/citations/10362352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10362352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10362352 | http://www.w3.org/2000/01/rdf-schema#comment | "The proto-oncoprotein Bcl-3 is a member of the IkappaB family and is present predominantly in the nucleus. To gain insight into specific nuclear functions of Bcl-3 we have isolated proteins that interact with its ankyrin repeat domain. Using the yeast two-hybrid-system we identified four novel binding partners of Bcl-3 in addition to NF-kappaB p50 and p52, previously known to associate with Bcl-3. The novel Bcl-3 interactors Jab1, Pirin, Tip60 and Bard1 are nuclear proteins which also bind to other transcription factors including c-Jun, nuclear factor I (NFI), HIV-1 Tat or the tumor suppressor and PolII holoenzyme component Brca1, respectively. Bcl-3, p50, and either Bard1, Tip60 or Pirin are sequestered into quarternary complexes on NF-kappaB DNA binding sites, whereas Jab1 enhances p50-Bcl-3-DNA complex formation. Furthermore, the histone acetylase Tip60 enhances Bcl-3-p50 activated transcription through an NF-kappaB binding site, indicating that quarternary complexes containing Bcl-3 interactors modulate NF-kappaB driven gene expression. These data implicate Bcl-3 as an adaptor between NF-kappaB p50/p52 and other transcription regulators and suggest that its gene activation function may at least in part be due to recruitment of the Tip60 histone actetylase."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202717"xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202717"xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Lehmann K."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Lehmann K."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Wulczyn F.G."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Wulczyn F.G."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Ansieau S."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Ansieau S."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Leutz A."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Leutz A."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Heissmeyer V."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Heissmeyer V."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Dechend R."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Dechend R."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Hirano F."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Hirano F."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Scheidereit C."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/author | "Scheidereit C."xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10362352 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |