| http://purl.uniprot.org/citations/10362660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10362660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10362660 | http://www.w3.org/2000/01/rdf-schema#comment | "With the use of the patch-clamp technique, five kinds of stretch-activated (SA) ion channels were identified on the basis of their single-channel conductances and ion selectivities in cultured chick ventricular myocytes. Because a high-conductance K+-selective channel predominated among these channels, we concentrated on characterizing its properties mostly using excised inside-out patches. With 145 mM KCl solution in the pipette and the bath, the channel had a conductance of 199.8 +/-8.2 pS (n = 22). The ion selectivities among K+, Na+, Ca2+, and Cl-as estimated from their permeability ratios were PNa/PK = 0.03, PCa/PK = 0.025, and PCl/PK = 0.026. The probability of the channel being open (Po) increased with the Ca2+ concentration in the bath ([Ca2+]b; dissociation constant Kd = 0.51 microM at +30 mV) and membrane potential (voltage at half-maximal Po = 39.4 mV at 0.35 microM [Ca2+]b). The channel was blocked by gadolinium, tetraethylammonium, and charybdotoxin from the extracellular surface and, consequently, was identified as a Ca2+-activated K+ (KCa) channel type. The channel was also reversibly activated by ATP applied to the intracellular surface (Kd = 0.74 mM at 0.10 microM [Ca2+]b at +30 mV). From these data taken together, we concluded that the channel is a new type of KCa channel that could be designated as an "SA KCa,ATP channel." To our knowledge, this is the first report of KCa channel in heart cells."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.1999.276.6.h1827"xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.1999.276.6.h1827"xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Sokabe M."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Sokabe M."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Matsubara T."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Matsubara T."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Naruse K."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Naruse K."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Hotta N."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Hotta N."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Kawakubo T."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/author | "Kawakubo T."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/pages | "H1827-H1838"xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/pages | "H1827-H1838"xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/title | "Characterization of a newly found stretch-activated KCa,ATP channel in cultured chick ventricular myocytes."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/title | "Characterization of a newly found stretch-activated KCa,ATP channel in cultured chick ventricular myocytes."xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/10362660 | http://purl.uniprot.org/core/volume | "276"xsd:string |