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http://purl.uniprot.org/citations/10364304http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10364304http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10364304http://www.w3.org/2000/01/rdf-schema#comment"In the immediate-early phase of reactivation or primary infection, herpesviruses express a small number of genes without requiring prior viral protein synthesis. Immediate-early genes usually encode regulatory proteins critical for the viral life cycle. Kaposi's sarcoma-associated herpesvirus (KSHV) gene transcription in the immediate-early stage of viral reactivation was examined by using a chemical induction combined with a gene expression screening method. RNA transcripts from at least four KSHV genomic loci accumulate when latently infected B-lymphoma cells are induced for reactivation in the presence of an inhibitor of protein synthesis (cycloheximide) and thus represent immediate-early class transcripts. Among them, a 3.6-kb mRNA encodes three putative open reading frames (ORFs), namely, ORF50, K8, and K8.2. ORF50 is a homologue of Rta, a transcription activator encoded by Epstein-Barr virus (EBV). The K8 gene codes for a 237-amino-acid protein with a basic-leucine zipper domain near its C terminus and an acidic domain near its N terminus and which closely resembles the ZEBRA protein of EBV and Jun/Fos family proteins. Other immediate-early mRNAs of KSHV include a 1. 7-kb mRNA encoding ORF45, a 2.0-kb mRNA encoding ORF K4.2, and a 4. 5-kb mRNA. Functional roles of products of these KSHV immediate-early transcripts remain to be studied."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.org/dc/terms/identifier"doi:10.1128/jvi.73.7.5556-5567.1999"xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/author"Yuan Y."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/author"Yuan Y."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/author"Zhu F.X."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/author"Zhu F.X."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/author"Cusano T."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/author"Cusano T."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/name"J Virol"xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/pages"5556-5567"xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/pages"5556-5567"xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/title"Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/title"Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus."xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/volume"73"xsd:string
http://purl.uniprot.org/citations/10364304http://purl.uniprot.org/core/volume"73"xsd:string
http://purl.uniprot.org/citations/10364304http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10364304
http://purl.uniprot.org/citations/10364304http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10364304
http://purl.uniprot.org/citations/10364304http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10364304
http://purl.uniprot.org/citations/10364304http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10364304
http://purl.uniprot.org/uniprot/Q9WRJ7http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10364304