| http://purl.uniprot.org/citations/10366024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10366024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10366024 | http://www.w3.org/2000/01/rdf-schema#comment | "The bcl-2 family of proteins comprises both anti-apoptotic and pro-apoptotic members, which play a pivotal role in regulating cell death. Bcl-w is a recently identified member of this family, which was shown to inhibit apoptosis in haemopoietic cell lines. However, the function and expression patterns of bcl-w in the nervous system have so far not been described. We have cloned complementary DNA corresponding to rat bcl-w and analysed the expression of bcl-w messenger RNA during rat brain development, using RNA blotting and in situ hybridization techniques. We also compared the expression patterns of bcl-w with those of bcl-xL. During brain development, the levels of bcl-w messenger RNA were found to increase, with highest expression located to specific regions of the mature brain, such as hippocampus, cerebellum, piriform cortex and locus coeruleus. Bcl-w messenger RNA was expressed by neurons, as shown with double labeling with neuronal markers. In contrast to bcl-w, bcl-xL messenger RNA expression levels were highest during early development, particularly in cortex, hippocampus, thalamus, spinal cord and dorsal root ganglia. During postnatal development the expression of bcl-xL messenger RNA decreased and were only detected at low levels in the adult nervous system. As shown earlier for bcl-2, the expression of bcl-w and bcl-x messenger RNA in cultured cerebellar granule cells was not altered by the deprivation of neurotrophic factors. The present results suggest that bcl-w may play an important role in the mature nervous system."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0306-4522(98)00642-3"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0306-4522(98)00642-3"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/author | "Hamner S."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/author | "Hamner S."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/author | "Lindholm D."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/author | "Lindholm D."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/author | "Skoglosa Y."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/author | "Skoglosa Y."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/pages | "673-684"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/pages | "673-684"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/title | "Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/title | "Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system."xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/10366024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10366024 |
| http://purl.uniprot.org/citations/10366024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10366024 |
| http://purl.uniprot.org/citations/10366024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10366024 |
| http://purl.uniprot.org/citations/10366024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10366024 |