| http://purl.uniprot.org/citations/10366629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10366629 | http://www.w3.org/2000/01/rdf-schema#comment | "The striatum integrates limbic and neocortical inputs to regulate sensorimotor and psychomotor behaviors. This function is dependent on the segregation of striatal projection neurons into anatomical and functional components, such as the striosome and matrix compartments. In the present study the association of ephrin-A cell surface ligands and EphA receptor tyrosine kinases (RTKs) with the organization of these compartments was determined in postnatal rats. Ephrin-A1 and ephrin-A4 selectively bind to EphA receptors on neurons restricted to the matrix compartment. Binding is absent from the striosomes, which were identified by mu-opioid receptor immunostaining. In contrast, ephrin-A2, ephrin-A3, and ephrin-A5 exhibit a different mosaic binding pattern that appears to define a subset of matrix neurons. In situ hybridization for EphA RTKs reveals that the two different ligand binding patterns strictly match the mRNA expression patterns of EphA4 and EphA7. Ligand-receptor binding assays indicate that ephrin-A1 and ephrin-A4 selectively bind EphA4 but not EphA7 in the lysates of striatal tissue. Conversely, ephrin-A2, ephrin-A3, and ephrin-A5 bind EphA7 but not EphA4. These observations implicate selective interactions between ephrin-A molecules and EphA RTKs as potential mechanisms for regulating the compartmental organization of the striatum."xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-12-04962.1999"xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/author | "Cassidy R.M."xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/author | "Kromer L.F."xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/author | "Janis L.S."xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/pages | "4962-4971"xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/title | "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum."xsd:string |
| http://purl.uniprot.org/citations/10366629 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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