DESCRIBE <http://purl.uniprot.org/citations/10368439>

Subject	Predicate	Object
http://purl.uniprot.org/citations/10368439	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10368439	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10368439	http://www.w3.org/2000/01/rdf-schema#comment	"Sequencing of an 8182-bp chromosomal region in Pseudomonas stutzeri revealed the major portion of an apparent mixed-function supraoperon (defined as a nested organization of transcriptional units encoding gene products which function in more than one biochemical pathway). A nearly identical supraoperon organization was apparent in the unpublished Pseudomonas aeruginosa genome database, where the complete Pseudomonas supraoperon was deduced. The serC(pdxF)-aroQp. pheA-hisHb-tyrAc-aroF-cmk-rpsA supraoperon encodes 3-phosphoserine aminotransferase, a bidomain chorismate mutase/prephenate dehydratase, imidazole acetol-phosphate aminotransferase, cyclohexadienyl dehydrogenase, 5-enolpyruvylshikimate 3-phosphate synthase, cytidylate kinase, and ribosomal protein S1. The member genes were identified by homology analysis, enzyme assay, and/or functional complementation. Although SerC(PdxF) and HisHb exercise their primary functions in serine, pyridoxine, and histidine biosynthesis, they also have critical catalytic roles in provision of the sidechain amino groups of tryptophan, phenylalanine, and tyrosine. The likelihood of supraoperon-wide translational coupling is suggested by the highly compressed intergenic spacing (including overlapping stop and start codons), as well as by possible hairpin structures in mRNA which may sequester some of the ribosome-binding sites and thus provide a mechanism for translational coupling. A comparison of the organization of the supraoperon genes in other organisms represented in the database revealed unmistakable conservation of the linkage of these genes across wide phylogenetic boundaries, albeit with considerable gene shuffling. At least remnants and shuffled portions of the entire supraoperon are distributed throughout the Gram-negative bacteria with the hisHb-tyrA-aroF gene block being conserved as distantly as the gram-positive bacteria. Such conservation of mixed-function genes may reflect the selective value of still-unknown global relationships of protein-protein interaction or regulation."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.org/dc/terms/identifier	"doi:10.1007/pl00006523"xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.org/dc/terms/identifier	"doi:10.1007/pl00006523"xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.org/dc/terms/identifier	"doi:10.1007/PL00006523"xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/author	"Xie G."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/author	"Xie G."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/author	"Jensen R.A."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/author	"Jensen R.A."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/author	"Bonner C.A."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/author	"Bonner C.A."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/date	"1999"xsd:gYear
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/date	"1999"xsd:gYear
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/name	"J. Mol. Evol."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/name	"J. Mol. Evol."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/pages	"108-121"xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/pages	"108-121"xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/title	"A probable mixed-function supraoperon in Pseudomonas exhibits gene organization features of both intergenomic conservation and gene shuffling."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/title	"A probable mixed-function supraoperon in Pseudomonas exhibits gene organization features of both intergenomic conservation and gene shuffling."xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/volume	"49"xsd:string
http://purl.uniprot.org/citations/10368439	http://purl.uniprot.org/core/volume	"49"xsd:string
http://purl.uniprot.org/citations/10368439	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/10368439
http://purl.uniprot.org/citations/10368439	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/10368439
http://purl.uniprot.org/citations/10368439	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/10368439