| http://purl.uniprot.org/citations/10373490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10373490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10373490 | http://www.w3.org/2000/01/rdf-schema#comment | "The product of the FEN2 gene of Saccharomyces cerevisiae has previously been described as a protein conferring sensitivity to the antifungal agent fenpropimorph. Fen2p was postulated to act as a common regulator of carbon and nitrogen catabolite repression and of amino acid and ergosterol biosynthesis. In this paper, we present experimental evidence characterizing Fen2p as a plasma membrane-localized transporter for the vitamin pantothenate. The high affinity transport system (Km = 3.5 microM) is sensitive to uncouplers, suggesting a H+-pantothenate cotransport. Pantothenate transport rates in yeast are modulated by extracellular pantothenate, being maximal at low pantothenate concentrations. It is demonstrated that beta-alanine can suppress the growth defect of FEN2 wild-type and fen2 mutant cells on pantothenate-free medium. Evidence is presented that beta-alanine is transported by the general amino acid permease Gap1p. The relation among pantothenate transport, nitrogen catabolite repression, and sensitivity to the antifungal agent fenpropimorph is discussed."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.26.18747"xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.26.18747"xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/author | "Sauer N."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/author | "Sauer N."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/author | "Stolz J."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/author | "Stolz J."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/pages | "18747-18752"xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/pages | "18747-18752"xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/title | "The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/title | "The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter."xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10373490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10373490 |
| http://purl.uniprot.org/citations/10373490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10373490 |
| http://purl.uniprot.org/citations/10373490 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10373490 |
| http://purl.uniprot.org/citations/10373490 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10373490 |
| http://purl.uniprot.org/uniprot/P19145 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10373490 |
| http://purl.uniprot.org/uniprot/P25621 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10373490 |