| http://purl.uniprot.org/citations/10377177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10377177 | http://www.w3.org/2000/01/rdf-schema#comment | "The human leukocyte antigen (HLA) restriction of the IgE response to different allergens in humans has been a subject of numerous published studies. However, the role and contribution of specific HLA class II molecules in the pathogenesis of allergic airway inflammation are unknown and difficult to assess. HLA-DQ6 and HLA-DQ8 transgenic mice lacking endogenous mouse class II gene expression were actively immunized and later challenged intranasally with short ragweed (SRW) allergenic extract. The HLA-DQ transgenic mice developed pulmonary eosinophilia and lung tissue damage. We also found an increase in total protein (TP) level and IL-5 production in bronchoalveolar lavage (BAL) fluid and an increase in SRW-specific Th2-type immunoglobulins (IgG1, IgG2b) and total serum IgE levels. Under similar treatment, DQ-negative full-sib control mice were normal. The allergic response could be significantly inhibited or abrogated in HLA-DQ mice by systemic treatment with anti-DQ mAb. The in vivo responses of HLA-DQ6 and HLA-DQ8 mice showed differences in terms of levels of eosinophilia, BAL protein, IL-5 concentration, and lung hyperreactivity to inhaled methacholine. These findings demonstrate the crucial role for specific HLA-DQ molecules in SRW-specific CD4(+) T-cell activation and resulting recruitment of eosinophils into the airways."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci6175"xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "David C.S."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "Krco C.J."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "Nabozny G.H."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "Andrews A.G."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "Chapoval S.P."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "Marietta E.V."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/author | "Raymond E.L."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/pages | "1707-1717"xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/title | "Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/10377177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10377177 |
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