| http://purl.uniprot.org/citations/10377345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10377345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10377345 | http://www.w3.org/2000/01/rdf-schema#comment | "Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans requires only the unc-49 gene. We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure. unc-49 contains a single copy of a GABA receptor N terminus, followed by three tandem copies of a GABA receptor C terminus. Using a single promoter, unc-49 generates three distinct GABAA receptor-like subunits by splicing the N terminus to each of the three C-terminal repeats. This organization suggests that the three UNC-49 subunits (UNC-49A, UNC-49B, and UNC-49C) are coordinately rescued and therefore might coassemble to form a heteromultimeric GABA receptor. Surprisingly, only UNC-49B and UNC-49C are expressed at high levels, whereas UNC-49A expression is barely detectable. Green fluorescent protein-tagged UNC-49B and UNC-49C subunits are coexpressed in muscle cells and are colocalized to synaptic regions. UNC-49B and UNC-49C also coassemble efficiently in Xenopus oocytes and HEK-293 cells to form a heteromeric GABA receptor. Together these data argue that UNC-49B and UNC-49C coassemble at the C. elegans neuromuscular junction. Thus, C. elegans is able to encode a heteromeric GABA receptor with a single locus."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-13-05348.1999"xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Beg A.A."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Beg A.A."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Bamber B.A."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Bamber B.A."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Twyman R.E."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/author | "Twyman R.E."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/pages | "5348-5359"xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/pages | "5348-5359"xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor."xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10377345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10377345 |
| http://purl.uniprot.org/citations/10377345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10377345 |
| http://purl.uniprot.org/citations/10377345 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10377345 |