| http://purl.uniprot.org/citations/10380924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10380924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10380924 | http://www.w3.org/2000/01/rdf-schema#comment | "During C. elegans development, Wnt/WG signaling is required for differences in cell fate between sister cells born from anterior/posterior divisions. A beta-catenin-related gene, wrm-1, and the lit-1 gene are effectors of this signaling pathway and appear to downregulate the activity of POP-1, a TCF/LEF-related protein, in posterior daughter cells. We show here that lit-1 encodes a serine/threonine protein kinase homolog related to the Drosophila tissue polarity protein Nemo. We demonstrate that the WRM-1 protein binds to LIT-1 in vivo and that WRM-1 can activate the LIT-1 protein kinase when coexpressed in vertebrate tissue culture cells. This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80784-9"xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80784-9"xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Sawa H."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Sawa H."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Yasuda J."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Yasuda J."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Shin T.H."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Shin T.H."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Okano H."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Okano H."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Priess J.R."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Priess J.R."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Rocheleau C.E."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/author | "Rocheleau C.E."xsd:string |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10380924 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |