| http://purl.uniprot.org/citations/10385124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10385124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10385124 | http://www.w3.org/2000/01/rdf-schema#comment | "Xeroderma pigmentosum variant (XP-V) is an inherited disorder which is associated with increased incidence of sunlight-induced skin cancers. Unlike other xeroderma pigmentosum cells (belonging to groups XP-A to XP-G), XP-V cells carry out normal nucleotide-excision repair processes but are defective in their replication of ultraviolet-damaged DNA. It has been suspected for some time that the XPV gene encodes a protein that is involved in trans-lesion DNA synthesis, but the gene product has never been isolated. Using an improved cell-free assay for trans-lesion DNA synthesis, we have recently isolated a DNA polymerase from HeLa cells that continues replication on damaged DNA by bypassing ultraviolet-induced thymine dimers in XP-V cell extracts. Here we show that this polymerase is a human homologue of the yeast Rad30 protein, recently identified as DNA polymerase eta. This polymerase and yeast Rad30 are members of a family of damage-bypass replication proteins which comprises the Escherichia coli proteins UmuC and DinB and the yeast Rev1 protein. We found that all XP-V cells examined carry mutations in their DNA polymerase eta gene. Recombinant human DNA polymerase eta corrects the inability of XP-V cell extracts to carry out DNA replication by bypassing thymine dimers on damaged DNA. Together, these results indicate that DNA polymerase eta could be the XPV gene product."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.org/dc/terms/identifier | "doi:10.1038/21447"xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.org/dc/terms/identifier | "doi:10.1038/21447"xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Araki M."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Araki M."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Hanaoka F."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Hanaoka F."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Iwai S."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Iwai S."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Yamada A."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Yamada A."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Dohmae N."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Dohmae N."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Takio K."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Takio K."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Yuasa M."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Yuasa M."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Yokoi M."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Yokoi M."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Masutani C."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Masutani C."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Kusumoto R."xsd:string |
| http://purl.uniprot.org/citations/10385124 | http://purl.uniprot.org/core/author | "Kusumoto R."xsd:string |