| http://purl.uniprot.org/citations/10390216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10390216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10390216 | http://www.w3.org/2000/01/rdf-schema#comment | "From genomic DNA of the clinical isolate Nocardia farcinica VIC, a 1. 6-kb Sau3AI fragment was cloned and expressed in Escherichia coli JM109. The recombinant strain expressed a beta-lactamase (pI, 4.6), FAR-1, which conferred high levels of resistance to amoxicillin, piperacillin, ticarcillin, and cephalothin. The hydrolysis constants (kcat, Km, Ki, and 50% inhibitory concentration) confirmed the MIC results and showed that FAR-1 activity is inhibited by clavulanic acid and at a low level by tazobactam and sulbactam. Moreover, FAR-1 beta-lactamase hydrolyzes aztreonam (at a low level) without significant activity against ceftazidime, cefotaxime and imipenem. FAR-1 mature protein of molecular mass ca 32 kDa, has less than 60% amino acid identity with any other class A beta-lactamases, being most closely related to PEN-A from Burkholderia cepacia (52%). A blaFAR-1-like gene was found in all studied N. farcinica strains, underlining the constitutive origin of this gene."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.org/dc/terms/identifier | "doi:10.1128/aac.43.7.1644"xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.org/dc/terms/identifier | "doi:10.1128/aac.43.7.1644"xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Nordmann P."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Nordmann P."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Poirel L."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Poirel L."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Naas T."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Naas T."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Boiron P."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Boiron P."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Chaibi E.B."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Chaibi E.B."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Labia R."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Labia R."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Laurent F."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/author | "Laurent F."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/name | "Antimicrob. Agents Chemother."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/name | "Antimicrob. Agents Chemother."xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/pages | "1644-1650"xsd:string |
| http://purl.uniprot.org/citations/10390216 | http://purl.uniprot.org/core/pages | "1644-1650"xsd:string |