http://purl.uniprot.org/citations/10390370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10390370 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an NMDA receptor-associated protein, bound the type I protein phosphatase (PP1) and the adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of NMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.285.5424.93"xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Lin J.W."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Sheng M."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Fraser I.D."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Langeberg L.K."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Tavalin S.J."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Alto N.M."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/author | "Westphal R.S."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/pages | "93-96"xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/title | "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex."xsd:string |
http://purl.uniprot.org/citations/10390370 | http://purl.uniprot.org/core/volume | "285"xsd:string |
http://purl.uniprot.org/citations/10390370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10390370 |
http://purl.uniprot.org/citations/10390370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10390370 |
http://purl.uniprot.org/uniprot/Q99996#attribution-53349F1E5BB65D8418EC2863FBC81839 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10390370 |
http://purl.uniprot.org/uniprot/Q99996#attribution-F03E0F5892CAD947C4D3554671ADD15C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10390370 |