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http://purl.uniprot.org/citations/10390370http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10390370http://www.w3.org/2000/01/rdf-schema#comment"Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an NMDA receptor-associated protein, bound the type I protein phosphatase (PP1) and the adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of NMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.org/dc/terms/identifier"doi:10.1126/science.285.5424.93"xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Scott J.D."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Lin J.W."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Sheng M."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Fraser I.D."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Langeberg L.K."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Tavalin S.J."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Alto N.M."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/author"Westphal R.S."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/pages"93-96"xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/title"Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex."xsd:string
http://purl.uniprot.org/citations/10390370http://purl.uniprot.org/core/volume"285"xsd:string
http://purl.uniprot.org/citations/10390370http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10390370
http://purl.uniprot.org/citations/10390370http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10390370
http://purl.uniprot.org/uniprot/Q99996#attribution-53349F1E5BB65D8418EC2863FBC81839http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10390370
http://purl.uniprot.org/uniprot/Q99996#attribution-F03E0F5892CAD947C4D3554671ADD15Chttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10390370