| http://purl.uniprot.org/citations/10391246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10391246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10391246 | http://www.w3.org/2000/01/rdf-schema#comment | "The signalling protein Wnt regulates transcription factors containing high-mobility-group (HMG) domains to direct decisions on cell fate during animal development. In Caenorhabditis elegans, the HMG-domain-containing repressor POP-1 distinguishes the fates of anterior daughter cells from their posterior sisters throughout development, and Wnt signalling downregulates POP-1 activity in one posterior daughter cell called E. Here we show that the genes mom-4 and lit-1 are also required to downregulate POP-1, not only in E but also in other posterior daughter cells. Consistent with action in a common pathway, mom-4 and lit-1 exhibit similar mutant phenotypes and encode components of the mitogen-activated protein kinase (MAPK) pathway that are homologous to vertebrate transforming-growth-factor-beta-activated kinase (TAK1) and NEMO-like kinase (NLK), respectively. Furthermore, MOM-4 and TAK1 bind related proteins that promote their kinase activities. We conclude that a MAPK-related pathway cooperates with Wnt signal transduction to downregulate POP-1 activity. These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.org/dc/terms/identifier | "doi:10.1038/21666"xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.org/dc/terms/identifier | "doi:10.1038/21666"xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Meneghini M.D."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Meneghini M.D."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Bowerman B."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Bowerman B."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Carter J.C."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Carter J.C."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Hamill D.R."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Hamill D.R."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Thorpe C.J."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Thorpe C.J."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Hisamoto N."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Hisamoto N."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10391246 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |