| http://purl.uniprot.org/citations/10393178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393178 | http://www.w3.org/2000/01/rdf-schema#comment | "Colony-stimulating factor-1 (CSF-1) activation of the CSF-1 receptor (CSF-1R) causes Cbl protooncoprotein tyrosine phosphorylation, Cbl-CSF-1R association and their simultaneous multiubiquitination at the plasma membrane. The CSF-1R is then rapidly internalized and degraded, whereas Cbl is deubiquitinated in the cytoplasm without being degraded. We have used primary macrophages from gene-targeted mice to study the role of Cbl. Cbl-/-macrophages form denser colonies and, at limiting CSF-1 concentrations, proliferate faster than Cbl+/+ macrophages. Their CSF-1Rs fail to exhibit multiubiquitination and a second wave of tyrosine phosphorylation previously suggested to be involved in preparation of the CSF-1-CSF-1R complex for endocytosis. Consistent with this result, Cbl-/-macrophage cell surface CSF-1-CSF-1R complexes are internalized more slowly, yet are still lysosomally degraded, and the CSF-1 utilization by Cbl-/-macrophages is reduced approximately 2-fold. Thus, attenuation of proliferation by Cbl is associated with its positive regulation of the coordinated multiubiquitination and endocytosis of the activated CSF-1R, and a reduction in the time that the CSF-1R signals from the cell surface. The results provide a paradigm for studies of the mechanisms underlying Cbl attenuation of proliferative responses induced by ligation of receptor tyrosine kinases."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.13.3616"xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.13.3616"xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Murphy M.A."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Murphy M.A."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Dominguez M.G."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Dominguez M.G."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Lee P.S."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Lee P.S."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Bowtell D.D."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Bowtell D.D."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Stanley E.R."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Stanley E.R."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Yeung Y.G."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/author | "Yeung Y.G."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/pages | "3616-3628"xsd:string |
| http://purl.uniprot.org/citations/10393178 | http://purl.uniprot.org/core/pages | "3616-3628"xsd:string |